Acidic microenvironment and bone pain in cancer-colonized bone

Acidic microenvironment and bone pain in cancer-colonized bone.

Solid cancers and hematologic cancers frequently colonize bone and induce skeletal-related complications. Bone pain is one of the most common complications associated with cancer colonization in bone and a major cause of increased morbidity and diminished quality of life, leading to poor survival in cancer patients. Although the mechanisms responsible for cancer-associated bone pain (CABP) are ...

Tumor Tissue-Derived Formaldehyde and Acidic Microenvironment Synergistically Induce Bone Cancer Pain

BACKGROUND There is current interest in understanding the molecular mechanisms of tumor-induced bone pain. Accumulated evidence shows that endogenous formaldehyde concentrations are elevated in the blood or urine of patients with breast, prostate or bladder cancer. These cancers are frequently associated with cancer pain especially after bone metastasis. It is well known that transient receptor...

Cancer Cell Colonisation in the Bone Microenvironment

Bone metastases are a common complication of epithelial cancers, of which breast, prostate and lung carcinomas are the most common. The establishment of cancer cells to distant sites such as the bone microenvironment requires multiple steps. Tumour cells can acquire properties to allow epithelial-to-mesenchymal transition, extravasation and migration. Within the bone metastatic niche, dissemina...

Cancer induced bone pain.

Interactions between microenvironment and cancer cells in two animal models of bone metastasis Running title: Bone microenvironment and cancer cells

The preferential proliferation of cancer cells in the bone microenvironment is poorly characterized. Expression pattern of bone marrow and other organs microenvironment in contact with osteolytic (Walker W256) and osteoblastic (MatLyLu MLL) metastases were investigated. Fisher and Copenhagen rats received respectively W256 and MLL cells injection. Bone and soft tissues were analyzed by immunoch...